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Multi-state models for event history analysis

Department of Biostatistics, University of Copenhagen, Denmark and Danish Epidemiology Science Centre, Copenhagen, Denmark, pka{at}biostat.ku.dk

Niels Keiding

Department of Biostatistics, University of Copenhagen, Denmark

An introduction to event history analysis via multi-state models is given. Examples include the two-state model for survival analysis, the competing risks and illness-death models, and models for bone marrow transplantation. Statistical model specification via transition intensities and likelihood inference is introduced. Consequences of observational patterns are discussed, and a real example concerning mortality and bleeding episodes in a liver cirrhosis trial is discussed.

Statistical Methods in Medical Research, Vol. 11, No. 2, 91-115 (2002)
DOI: 10.1191/0962280202SM276ra


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