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Statistical Methods in Medical Research
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Ethical issues in oncology biostatistics

Peter F Thall

Department of Biostatistics, University of Texas, USA, rex{at}mdanderson.org

A medical statistician’s routine professional activitiesare likely to have important ethical consequences. This is due in part to the fact that good medical practice and scientifically valid medical research both require as precursors high quality statistical design and data analysis. In this paper I discuss various ethical issues that I have encountered while working as a biostatistician at M.D. Anderson Cancer Center. I describe particular experiences and the ethical issues involved. Topics include medical decision making, benefit-harm tradeoffs, safety monitoring, adaptive randomization, informed consent, and publication bias.

Statistical Methods in Medical Research, Vol. 11, No. 5, 429-448 (2002)
DOI: 10.1191/0962280202sm301ra


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