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Statistical Methods in Medical Research, Vol. 16, No. 1, 51-64 (2007)
DOI: 10.1177/0962280206070652

Developing international consensus on measures of improvement for patients with myositis

Peter A. Lachenbruch

FDA Center for Biologics Evaluation and Research, USA, lachenbruchpa{at}aol.com

Frederick W. Miller

National Institute of Environmental Health Sciences, USA

Lisa G. Rider

National Institute of Environmental Health Sciences, USA

We discuss methods of developing consensus in measuring improvement in myositis. We consider selecting candidate variables, reliability and validity, percentage improvement/worsening rules, rules based on CART and logistic regression. We discuss criteria for determining an acceptable rule that include both numerical measures and physician acceptance.


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