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Statistical Methods in Medical Research
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0962280207081606v1
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What's this?

Stratified and randomized play-the-winner rule

Yuanyuan Liang

Alberta Research Centre for Child Health Evidence, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada

Kimmie Chough Carriere

Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton, Alberta, Canada, kccarrie{at}ualberta.ca

In this paper, a new allocation rule for treatment assignments in sequential clinical trials is proposed. The stratified and randomized play-the-winner rule (SRPWR) is an extension of the randomized play-the-winner rule to more than two treatments. It is applicable to cases where the probabilities of success of a treatment depend on both treatments and known confounders (e.g., patient's age, gender and disease status). On average, demonstrate that the SRPWR assigns more patients to the better treatment, while eliminating the selection bias and allowing delayed responses to treatments.

This version was published on December 1, 2008

Statistical Methods in Medical Research, Vol. 17, No. 6, 581-593 (2008)
DOI: 10.1177/0962280207081606
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