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Statistical Methods in Medical Research
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Statistical methods for population pharmacokinetic modelling

Amy Racine-Poon

Pharma Division, Novartis, Basel, Switzerland and, wara{at}chbs.ciba.com

Jon Wakefield

Department of Epidemiology and Public Health, Imperial College School of Medicine, St Mary's Hospital, London, UK

A principal aim of population pharmacokinetic studies is to estimate the variance components associated with intra- and inter-individual variability in observed drug concentrations. The explanation of the inter-individual variability in terms of subject-specific covariates is also of great importance. Pharmacokinetic models are nonlinear in the parameters and estimation is not straightforward. Within this paper we review a number of estimation approaches which have been suggested for population pharmacokinetic analyses. We distinguish between Bayesian and non-Bayesian and fully-parametric, semi-parametric and nonparametric methods.

Statistical Methods in Medical Research, Vol. 7, No. 1, 63-84 (1998)
DOI: 10.1177/096228029800700106
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