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Correcting for verification bias in studies of a diagnostic test's accuracy

Division of Biostatistics, Department of Medicine, Indiana University School of Medicine, and the Regenstrief Institute for Health Care, Indianapolis, USA, azhou{at}iupui.edu

Standard methods for assessing the accuracy of diagnostic tests require determination of true disease status for each study patient. In practice, some study patients might not have verified disease status. If the decision to verify a patient is influenced by the test result, analysis using only verified cases might lead to biased results, commonly known as verification bias. This paper reviews recent developments in bias-correction methods for studies on the accuracy of diagnostic tests.

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