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Statistical Methods in Medical Research
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0962280206075524v1
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Article

Evaluation of change in CD4+ cell counts in AIDS clinical trials

Hua Liang*

Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, USA

* To whom correspondence should be addressed.


  Abstract

To evaluate the antiretroviral activity of antiretroviral agents and to compare the effects of two different antiretroviral agents, we propose a non-parametric mixed-effects model to investigate change of CD4+ counts. The proposed model and methods are applied to analyse the data from PACTG345 study. Population and individual patterns of change of CD4+ counts and a reference band are obtained. Our results indicate that treatment with high-dose ritonavir is significantly superior compared with low-dose ritonavir.

First published on August 14, 2007, doi:10.1177/0962280206075524

Statistical Methods in Medical Research 2008;17:141.

A more recent version of this article appeared on April 1, 2008

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