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Statistical Methods in Medical Research
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0962280208096046v1
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Article

Efficient sampling approaches to address confounding in database studies

James A. Hanley1* and Nandini Dendukuri2

1 Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada
2 Technology Assessment Unit, McGill University Health Centre, and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada

* To whom correspondence should be addressed.


  Abstract

Administrative and other population-based databases are widely used in pharmacoepidemiology to study the unintended effects of medications. They allow investigators to study large case series, and they document prescription medication exposure without having to contact individuals or medical charts, or rely on human recall. However, such databases often lack information on potentially important confounding variables. This review describes some of the sampling approaches and accompanying data-analysis methods that can be used to assess, and deal efficiently with, such confounding.

First published on September 24, 2008, doi:10.1177/0962280208096046

Statistical Methods in Medical Research 2009;18:81.

A more recent version of this article appeared on February 1, 2009

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