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Statistical Methods in Medical Research, Vol. 4, No. 3,
187-196 (1995)
DOI: 10.1177/096228029500400302
Generalized additive models for medical research
Trevor Hastie
Department of Statistics and Division of Biostatistics, Stanford University, Stanford, California, USA
Robert Tibshirani
Department of Statistics and Division of Biostatistics, Stanford University, Stanford, California, USA
This article reviews flexible statistical methods that are useful for characterizing the effect of potential prognostic factors on disease endpoints. Applications to survival models and binary outcome models are illustrated.

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